Endocannabinoid system involvement in brain reward processes related to drug abuse
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چکیده
منابع مشابه
The endocannabinoid system in brain reward processes.
Food, drugs and brain stimulation can serve as strong rewarding stimuli and are all believed to activate common brain circuits that evolved in mammals to favour fitness and survival. For decades, endogenous dopaminergic and opioid systems have been considered the most important systems in mediating brain reward processes. Recent evidence suggests that the endogenous cannabinoid (endocannabinoid...
متن کاملInvolvement of the endocannabinoid system in drug addiction.
Recent studies have shown that the endocannabinoid system is involved in the common neurobiological mechanism underlying drug addiction. This system participates in the primary rewarding effects of cannabinoids, nicotine, alcohol and opioids, through the release of endocannabinoids in the ventral tegmental area. Endocannabinoids are also involved in the motivation to seek drugs by a dopamine-in...
متن کاملEndocannabinoid signaling system and brain reward: emphasis on dopamine.
The brain's reward circuitry consists of an "in series" circuit of dopaminergic (DA) neurons in the ventral tegmental area (VTA), nucleus accumbens (Acb), and that portion of the medial forebrain bundle (MFB) which links the VTA and Acb. Drugs which enhance brain reward (and have derivative addictive potential) have common actions on this core DA reward system and on animal behaviors relating t...
متن کاملAn endocannabinoid hypothesis of drug reward
The dopamine hypothesis of drug reward remains a difficult area of research and perhaps a major problem and hindrance to progress in unraveling the biology of addiction. Pharmacological treatment of drug dependency has been disappointing and new therapeutic targets and hypotheses are needed. Since there is accumulating evidence indicating a central role of endocannabinoid physiological control ...
متن کاملRegulation of brain reward by the endocannabinoid system: a critical review of behavioral studies in animals.
The endocannabinoid system has been implicated in the regulation of a variety of physiological processes, including a crucial involvement in brain reward systems and the regulation of motivational processes. Behavioral studies have shown that cannabinoid reward may involve the same brain circuits and similar brain mechanisms with other drugs of abuse, such as nicotine, cocaine, alcohol and hero...
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ژورنال
عنوان ژورنال: Pharmacological Research
سال: 2007
ISSN: 1043-6618
DOI: 10.1016/j.phrs.2007.09.005